Laboratory
of
Sphingolipid Biology
About Us
Finding Inspiration in Every Turn !
PhD Students
Trishna Pani
ICMR-SRF
M.Sc. Biotechnology, Vellore Institute of Technology, 2014
I am interested in deciphering the transcriptional and post-transcriptional alterations in sphingolipid and ganglioside genes during tumor progression. I am focused on understanding the molecular mechanisms orchestrating these alterations and their role in tumor progression.
Devashish Mehta
ICMR-SRF
M.Pharma. (Medicinal Chemistry), Central University of Punjab, 2019
My work is focused on the design and synthesis of bile acid-based biomaterials. Bile acids have excellent chemistry to act as scaffolds for the attachment of bioactive molecules. Moreover, their amphiphilic nature aids their entry via the biological membranes. I am developing bile acid-based membrane targeting antimicrobials and bile acid-derived anticancer molecules.
Nafees Ansari
ICMR-SRF
M.Sc. Microbiology, Central University of Rajasthan, 2016
I am interested in building metabolic-signalling-gene regulatory circuits connecting
sphingolipid and ganglioside pathways with cancer progression. I am also interested
to see alterations in chromatin accessibility in context of metabolic signalling during
breast cancer progression.
Somesh Kumar Jha
Ph.D. -JRF, Regional Centre for Biotechnology, Faridabad
M.Sc. Biotechnology (Int. PhD.), Regional Centre for Biotechnology, 2020
I am working on the role of immune and lipid regulations in the tumor
microenvironment. One of the aspect Iam working on is to delineate the role of
epigenetic modification mediated proteasomal regulation in different murine tumor
microenvironments. The other aspect I am pursuing, is, to study the role of lipid
dysregulation in murine liver cancer models and designing strategies to mitigate it.
Ali Khan
PhD-SRF
M.Sc. Physics, Thapar Institute of Engineering and Technology, 2019
I work on identifying and validating alterations in lipids, like sphingolipids,
phospholipids, eicosanoids and gangliosides as diagnostic and therapeutic targets
for liver diseases like NASH, NAFL, liver cancer, and different subtypes of breast
cancer. I aim to identify and validate the lipid-based signatures from patient samples to use them as potential diagnostic and prognostic biomarkers.
Somdeb Chatterjee
PhD-JRF
M.Tech. Biotechnology, KIIT Bhubaneshwar, 2018
Computational methods can serve as a valuable tool for modeling metabolism in
humans; allowing us to better understand disease states, identify key reactions and
probe their response to perturbations. My interest is in computational biology, with
work revolving around constraint-based modeling and simulation of various aspects
of sphingolipid metabolism in the context of breast cancer.
Rajeshwari tripathi
PhD-JRF
M.Sc. Zoology, Kumaun University, Nainital, 2019
I am working on understanding the regulation of sphingolipids and eicosanoids in
progression of Inflammatory Bowel Diseases (IBD) and identify lipid signatures that
can distinguish between different subtypes of IBD. Iam also interested to see the
transcriptional regulation of lipid pathways in different subtypes of breast cancer.
Kirti Mishra
PhD-JRF
I am working on understanding the regulation of sphingolipids and eicosanoids in
progression of Inflammatory Bowel Diseases (IBD) and identify lipid signatures that
can distinguish between different subtypes of IBD. Iam also interested to see the
transcriptional regulation of lipid pathways in different subtypes of breast cancer.
Visiting Students
Dolly Jain
Ph.D-SRF, Regional Centre for Biotechnology, Faridabad
M.Sc. Biomedical Sciences, Dr. BR. Ambedkar Center for Biomedical Research, University of Delhi, 2019
I am working on exploring the impact of different therapeutic interventions on chemotherapy-mediated tumor regression. Dietary restriction regimens including caloric restriction and fasting have emerged as promising strategies to sensitize cancer cells towards chemotherapy while protecting the normal cells. I am exploring the impact of dietary restriction on chemotherapy-mediated tumor regression, and its impact on the tumor microenvironment. Apart from cancer cell-immune cell interactions, cancer cell-neuron interactions are crucial for tumor progression. I am also developing innovative strategies to alter the tumor microenvironment by targeting the cancer cell-neuron interactions.
Jasleen Kaur
PhD-JRF, National Institute of Immunology, Delhi
M.Sc. Life Sciences, Bose Institute Kolkata, 2021
Ankur
JRF
M.Sc. (Biotechnology), BHU, 2023
I delves deeper into the sphingolipid-mediated regulation of mTORC2 pathway in multiple cancer models. He is dissecting the intricate coss-talk between RICTOR, the regulatory subunit of mTORC2, and key sphingolipid species for modulating the tumor microenvironment during tumor progression.
Trainee
Bharti Rose
M.Sc. (Biotechnology), Amity University Gurgaon, 2023