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About Us

Finding Inspiration in Every Turn !

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PhD Students

 
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Animesh Kar 

ICMR-SRF
M.Sc. Biophysics, All India Institute of Medical Sciences, 2016

My work involves studying epigenetic, transcriptional, and post-transcriptional mechanisms regulating diverse signaling pathways during tumor development, and those targeting the tumor microenvironment in response to cancer chemotherapeutics.

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Kajal Rajput

PhD-SRF

M.Sc. Microbial Biotechnology, Maharishi Dayanand University, 2017

 

I am working on understanding the role of mTORC2-mediated regulation of sphingolipid metabolism in breast cancer progression. I am also working on identifying the unique sphingolipid signatures in different subtype-specific breast cancer cell lines and clinical samples.

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Trishna Pani

ICMR-SRF
M.Sc. Biotechnology, Vellore Institute of Technology, 2014

I am interested in deciphering the transcriptional and post-transcriptional alterations in sphingolipid and ganglioside genes during tumor progression. I am focused on understanding the molecular mechanisms orchestrating these alterations and their role in tumor progression.

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Devashish Mehta

ICMR-SRF
M.Pharma. (Medicinal Chemistry), Central University of Punjab, 2019

 

My work is focused on the design and synthesis of bile acid-based biomaterials. Bile acids have excellent chemistry to act as scaffolds for the attachment of bioactive molecules. Moreover, their amphiphilic nature aids their entry via the biological membranes. I am developing bile acid-based membrane targeting antimicrobials and bile acid-derived anticancer molecules.

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Nafees Ansari

ICMR-SRF
M.Sc. Microbiology, Central University of Rajasthan, 2016

 

I am interested in building metabolic-signaling-gene regulatory circuits connecting
sphingolipid and ganglioside pathways with cancer progression. I am also trying to
understand microRNA mediated regulation of inflammation in a colon cancer model.

 
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Ali Khan

PhD-SRF
M.Sc. Physics, Thapar Institute of Engineering and Technology, 2019

 

My work deals with identifying and validating the alterations in sphingolipids, glycerolipids, phospholipids, and gangliosides as diagnostic and therapeutic targets for liver diseases like NASH, NAFLD, cirrhosis, liver cancer, and different subtypes of breast cancer. I aim to identify and validate the lipid-based signatures from patient samples to use them as potential diagnostic and prognostic biomarkers.

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Somdeb Chatterjee

PhD-JRF

M.Tech. Biotechnology, KIIT Bhubaneshwar, 2018

 

My interest is in computational biology, with work revolving around the modeling and simulation of various aspects of sphingolipid metabolism in the context of breast cancer. Computational methods can serve as a valuable tool for modeling metabolism in humans; allowing us to better understand disease states, identify key reactions and probe their response to perturbations.

Visiting Students

 
 
 
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Poonam Yadav

Ph.D-SRF, Regional Centre for Biotechnology, Faridabad
M.Sc. Biochemistry, Central University of Haryana, 2017 

Heterogeneous and complex nature of the tumor microenvironment (TME) poses a serious challenge for the poor efficacy of chemotherapeutic drugs. TME composed of endothelial cells, macrophages, cancer-associated fibroblasts and extracellular matrix (ECM) provides a conducive environment with enhanced angiogenesis and inflammation to dangerously proliferating cells, protects them from immune recognition, and helps in invasion followed by metastasis. Therefore, only the death of cancer cells with anticancer drugs is not sufficient to tackle complex and heterogenous tumor tissues. I am working on the engineering of chimeric nanomicelles for the simultaneous targeting of multiple processes in the tumor microenvironment (TME) for cancer treatment.

 
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Dolly Jain

Ph.D-SRF, Regional Centre for Biotechnology, Faridabad
M.Sc. Biomedical Sciences, Dr. BR. Ambedkar Center for Biomedical Research, University of Delhi, 2019

I am working on exploring the impact of different therapeutic interventions on chemotherapy-mediated tumor regression. Dietary restriction regimens including caloric restriction and fasting have emerged as promising strategies to sensitize cancer cells towards chemotherapy while protecting the normal cells. I am exploring the impact of dietary restriction on chemotherapy-mediated tumor regression, and its impact on the tumor microenvironment. Apart from cancer cell-immune cell interactions, cancer cell-neuron interactions are crucial for tumor progression. I am also developing innovative strategies to alter the tumor microenvironment by targeting the cancer cell-neuron interactions.

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Somesh Kumar Jha

Ph.D-JRF, Regional Centre for Biotechnology, Faridabad

M.Sc. Biotechnology (Int.PhD.), Regional Centre for Biotechnology, 2020

My work is focused on the use of various immunogenic cell death (ICD) inducing drugs in combination with immune adjuvants to unleash the anti-tumorigenic potential of the immune system that could effectively impede tumor growth and increase survivability. Furthermore, we have developed a bile acid-based hydrogel system as a drug delivery vehicle that is being used to locally deliver the combination of ICD-inducing drugs and immune adjuvants across different tumor models. Apart from this, I have been working on a chemical-induced mice model of hepatocellular carcinoma. Herein we are exploring the therapeutic potential of phospholipid-derived bile acid conjugates of different chemotherapeutic drugs.

 
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Jasleen Kaur

PhD-JRF, National Institute of Immunology, Delhi

M.Sc. Life Sciences, Bose Institute Kolkata, 2021

 
 

Trainee

 
 
 
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Surabhi

MSc Biotechnology, Amity University Haryana

 
 
 
 
 
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