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Publications

Key Publications as Independent PI

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  1. M. N. Ansari, S. K. Jha, A. Khan, K. Rajput, N. Pandey, D. Jain, R. Tripathi, N. Medatwal, P. Sharma, S. Datta, A. Kar, T. Pani, S. A. Ali, K. Cholke, K. Rana, V. P. Snijesh, G. Mukherjee, S. V. S. Deo, S. Basak, A. Mishra, J. S. Prabhu, A. Mukhopadhyay, A. Bajaj, U. Dasgupta* (2025) The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms. PLoS Biol 23, e3003362 (IF 7.8). 10.1371/journal.pbio.3003362.

  2. D. Mehta, K. Rajput, D. Jain, A. Bajaj, and U. Dasgupta* (2024) Unveiling the Role of Mechanistic Target of Rapamycin Kinase (MTOR) Signaling in Cancer Progression and the Emergence of MTOR Inhibitors as Therapeutic Strategies. ACS. Pharmacol. Transl. Sci. 7 (12), 3758 (IF 5.1). 10.1021/acsptsci.4c0053.

  3. A. Kar, S. Agarwal, A. Singh, A. Bajaj, and U. Dasgupta* (2024) Insights into Molecular Mechanisms of Chemotherapy Resistance in Cancer. Transl. Oncol., 42, 10190. (IF 5.0). 10.1016/j.tranon.2024.101901.

  4. A. Kar, D. Jain, S. Kumar, K. Rajput, S. Pal, K. Rana, R. Kar, S. K. Jha, N. Medatwal, P. S. Yavvari, D. Mehta, M K. Pradhan, N Pandey, A. Srivastava, A. Mukhopadhyay, U. Agarwal, S. Sengupta, V. S.Patil, A. Bajaj, and U. Dasgupta* (2023) A Localized Hydrogel-mediated Chemotherapy Causes Immunogenic Cell Death via Activation of Ceramide-mediated Unfolded Protein Response. Sci. Adv.,9, eadf2746 (IF 14.1). 10.1126/sciadv.adf2746.

  5. A. Kar, N. Medatwal, K. Rajput,  T. Pani, P. Sharma, A. S. Oberoi, G. Vishwakarma, SVS Deo, A. Bajaj, and U. Dasgupta* (2023) Unique Sphingolipid Signature Identifies Luminal and Triple-Negative Breast Cancer Subtypes Int. J. Cancer  1-14. (IF 7.3).10.1002/ijc.34423.

  6. K. Rajput, M. N. Ansari, S. K. Jha, T. Pani, N. Medatwal, S. D. Chattopadhyay, A. Bajaj, and U. Dasgupta* (2022) Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells. Cancers 14, 4496. (IF 6.6). 10.3390/cancers14184496.

  7. K. Rajput, M. N. Ansari, S. K. Jha, N.  Medatwal, P. Sharma, S. Datta, A. Kar, T. Pani, K. Cholke, K. Rana, A. Khan, G. Mukherjee, SVS. Deo, J. S. Prabhu, A. Mukhopadhyay, A Bajaj* and U. Dasgupta* (2022) mTORC2 Drives ZFX-mediated Ganglioside Biosynthesis to Promote Breast Cancer Progression, bioRxiv 2022.01.10.475595.

  8. T. Pani, K. Rajput, A. Kar, H. Sharma, R. Basak, N. Medatwal, S. Saha, G. Dev, S. Kumar, S. Gupta, A. Mukhopadhyay, D. Malakar, TK. Maiti, AG. Aneeshkumar, SVS. Deo, RD. Sharma, A. Bajaj and U. Dasgupta* (2021) Alternative Splicing of Ceramide Synthase 2 Alters Levels of Specific Ceramides and Modulates Cancer Cell Proliferation and Migration in Luminal B Breast Cancer Subtype.” Cell Death Dis. 12 (2), 171  (IF 8.4). 10.1038/s41419-021-03436-x.

  9. V. Sreekanth, A. Kar, S. Kumar, S. Pal, P. Yadav, Y. Sharma, V. Komalla, H. Sharma, R. Shyam, R. D. Sharma, A. Mukhopadhyay, S. Sengupta, U. Dasgupta* and A. Bajaj (2021) Bile Acid-tethered Docetaxel-based Nanomicelle Mitigates Tumor progression via Epigenetic Changes. Angew. Chem. Int. Ed.  60, 5394-5399 (IF 16.8). 10.1002/anie.202015173.

  10. N. Medatwal, M. N. Ansari, S. Kumar, S. Pal, K. Rana, U. Dasgupta* and A. Bajaj (2020) Hydrogel-mediated Delivery of Celastrol and Doxorubicin Induces Synergistic Effect on Tumor Regression via Upregulation of Ceramides. Nanoscale 12, 18463-18475. (IF- 7.79). 10.1039/d0nr01066a.

  11. S. Pal, N. Medatwal, S. Kumar, A. Kar, V. Komalla, P. S. Yavvari, D. K. Mishra, D. Malakar, M. Pillai, A. Srivastava, R. D. Sharma, S. Sengupta, U. Dasgupta* and A. Bajaj (2019) A Localized Chimeric Hydrogel Therapy Targets Tumor Microenvironment through Alteration of Sphingolipid Metabolism.  ACS Central Sci. 5, 1648-1662. (IF- 18.7). 10.1021/acscentsci.9b00551.

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Complete List of Publications

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  1. M. N. Ansari, S. K. Jha, A. Khan, K. Rajput, N. Pandey, D. Jain, R. Tripathi, N. Medatwal, P. Sharma, S. Datta, A. Kar, T. Pani, S. A. Ali, K. Cholke, K. Rana, V. P. Snijesh, G. Mukherjee, S. V. S. Deo, S. Basak, A. Mishra, J. S. Prabhu, A. Mukhopadhyay, A. Bajaj, U. Dasgupta* (2025) The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms. PLoS Biol 23, e3003362 (IF 7.8). 10.1371/journal.pbio.3003362.

  2. P. Yadav, K. Rana, R. Chakraborty, A. Khan, D. Mehta, D. Jain, B. Aggarwal, S. K. Jha, U. Dasgupta, and A. Bajaj (2024) Engineered Nanomicelles Targeting the Proliferation and Angiogenesis Inhibit the Tumour Progression by Impairing the Synthesis of Ceramide-1-Phosphate. Nanoscale, 16, 10350 – 10365. (IF 6.7). 10.1039/d3nr04806c.

  3. P. Yadav, K. Rana, V. Nardini, A. Khan, T. Pani, A. Kar, D. Jain, R. Chakraborty, R. Singh, S. K. Jha, D. Mehta, H. Sharma, R. D. Sharma, SVS Deo, S. Sengupta, V. S, Patil, L. H. Faccioli, U. Dasgupta, and A. Bajaj (2024) Engineered Nanomicelles Inhibit the Tumour Progression via Abrogating the Prostaglandin-mediated Immunosuppression. J. Control Release 368, 548-565. (IF 11.4). 10.1016/j.jconrel.2024.03.009.

  4. A. Kar, A. Agarwal, A. Singh, A. Bajaj, and U. Dasgupta* (2024) Insights into Molecular Mechanisms of Chemotherapy Resistance in Cancer. Transl. Oncol., 42, 10190. (IF 5.0). 10.1016/j.tranon.2024.101901.

  5. A. Kar, D. Jain, S. Kumar, K. Rajput, S. Pal, K. Rana, R. Kar, S. K. Jha, N. Medatwal, P. S. Yavvari, D. Mehta, M K. Pradhan, N Pandey, A. Srivastava, A. Mukhopadhyay, U. Agarwal, S. Sengupta, V. S.Patil, A. Bajaj, and U. Dasgupta* (2023) A Localized Hydrogel-mediated Chemotherapy Causes Immunogenic Cell Death via Activation of Ceramide-mediated Unfolded Protein Response. Sci. Adv.,9, eadf2746 (IF 14.1). 10.1126/sciadv.adf2746.

  6. H. Sharma T. Pani, U. Dasgupta, J. Batra and RD. Sharma (2023) Prediction of Transcript Structure and Concentration Using RNA-Seq Data. Brief. Bioinform. 1-9. (IF 11.6). 10.1093/bib/bbad022.

  7. T. Pani and  U. Dasgupta* (2023) Role of transcriptional and posttranscriptional regulation of sphingolipid genes in molecular heterogeneity of breast cancer. In: Garg M., Sethi G., Pandey AK. (eds) Transcription and Translation in Health and Disease: 37-47. Elsevier, Academic Press. (Book Chapter). 10.1016/B978-0-323-99521-4.00011-8.

  8. A. Kar, N. Medatwal, K. Rajput,  T. Pani, P. Sharma, A. S. Oberoi, G. Vishwakarma, SVS Deo, A. Bajaj, and U. Dasgupta* (2023) Unique Sphingolipid Signature Identifies Luminal and Triple-Negative Breast Cancer Subtypes Int. J. Cancer  1-14. (IF 7.3). 10.1002/ijc.34423.

  9. K. Rajput, M. N. Ansari, S. K. Jha, T. Pani, N. Medatwal, S. D. Chattopadhyay, A. Bajaj, and U. Dasgupta* (2022) Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells. Cancers 14, 4496. (IF-6.6). 10.3390/cancers14184496.

  10. D. Mehta, P. Yadav. U. Dasgupta, and A. Bajaj Advances in Nanoparticle-mediated Delivery of Docetaxel.” n Book entitled  "Application of Engineered Nanomaterials in Food and Drugs. (Invited Book Chapter). (Under Review)

  11. K. Rajput, M. N. Ansari, S. K. Jha, N.  Medatwal, P. Sharma, S. Datta, A. Kar, T. Pani, K. Cholke, K. Rana,2 A. Khan, G. Mukherjee, SVS Deo, J. S. Prabhu, A. Mukhopadhyay, A Bajaj* and U. Dasgupta* (2022) mTORC2 Drives ZFX-mediated Ganglioside Biosynthesis to Promote Breast Cancer Progression, bioRxiv 2022.01.10.475595.

  12. K. Rana, T. Pani, S. K. Jha, D. Mehta, P. Yadav, D. Jain, M. K. Pradhan, S. Mishra, R. Kar, B. Reshma G, A. Srivastava, U. Dasgupta, V. S. Patil, and A. Bajaj, (2022) Hydrogel-mediated Topical Delivery of Steroids Can Effectively Alleviate Psoriasis via Altering the Infiltration of Th17 and γδ T Cells. Nanoscale 14, 3834-3848. (IF- 7.79).10.1039/D1NR06001E

  13. S. Kumar, S. Pal, J. Thakur, P. Rani, K. Rana, A. Kar, R. Kar, D. Mehta, S. k. Jha, M. P. Pradhan, D. Jain, K. Rajput, S. Mishra, M. Ganguli, A. Srivastava, U. Dasgupta, V. S. Patil, and A. Bajaj, (2021) Nonimmunogenic hydrogel-mediated delivery of antibiotics outperforms clinically used formulations in mitigating wound infections, ACS Appl. Mater. Interfaces 13 (37), 44041-44053. IF (9.229). 10.1021/acsami.1c12265.

  14. S. Pal, V. Soni, S. Kumar, S. K. Jha, N. Medatwal, K. Rana, P. Yadav, D. Mehta, D. Jain, R. Kar, A. Srivastava, V. S. Patil, U. Dasgupta, V. Nandicoori, and A. Bajaj, (2021) A Hydrogel-based Implantable Multidrug Antitubercular Formulation Outperforms Oral Delivery. Nanoscale 13, 13225-13230. (IF- 7.790). 10.1039/d0nr08806d.

  15. S. Pal, D. Mehta, U. Dasgupta, and A. Bajaj, (2021) Advances in Engineering of Low Molecular Weight Hydrogels For Chemotherapeutic Applications. Biomed. Mater. 16, 024102. 10.1088/1748-605X/abdce1.

  16. T. Pani, K Rajput, A. Kar and U. Dasgupta* (2021) Alternative Splicing of CERS2 Promotes Cell Proliferation and Migration in Luminal B Subtype Breast Cancer Cells. Oncoscience 8, 50 (IF: 3.2) (Research perspective). 10.18632/oncoscience.531.

  17. T. Pani, K. Rajput, A. Kar, H. Sharma, R. Basak, N. Medatwal, S. Saha, G. Dev, S. Kumar, S. Gupta, A. Mukhopadhyay, D. Malakar, TK. Maiti, AG. Aneesh kumar, SVS. Deo, RD. Sharma, A. Bajaj and U. Dasgupta* (2021) Alternative Splicing of Ceramide Synthase 2 Alters Levels of Specific Ceramides and Modulates Cancer Cell Proliferation and Migration in Luminal B Breast Cancer Subtype.” Cell Death Dis. 12 (2), 171  (IF 8.4). 10.1038/s41419-021-03436-x.

  18. V. Sreekanth, A. Kar, S. Kumar, S. Pal, P. Yadav, Y. Sharma, V. Komalla, H. Sharma, R. Shyam, R. D. Sharma, A. Mukhopadhyay, S. Sengupta, U. Dasgupta* and A. Bajaj (2021) Bile Acid-tethered Docetaxel-based Nanomicelle Mitigates Tumor progression via Epigenetic Changes. Angew. Chem. Int. Ed.  60, 5394-5399 (IF 16.8). 10.1002/anie.202015173.

  19. N. Medatwal, M. N. Ansari, S. Kumar, S. Pal, K. Rana, U. Dasgupta* and A. Bajaj (2020) Hydrogel-mediated Delivery of Celastrol and Doxorubicin Induces Synergistic Effect on Tumor Regression via Upregulation of Ceramides. Nanoscale 12, 18463-18475. (IF- 7.790). 10.1039/d0nr01066a.

  20. S. Muzafar, R. D. Sharma, A. Shah, N. Gaur, U. Dasgupta, N. Chauhan, and R. Prasad (2020) Identification of Genome-Wide Alternative Splicing Events in Sequential, Isogenic Clinical Isolates of Candida albicans Reveals a Novel Mechanism of Drug Resistance and Tolerance to Cellular Stresses. mSphere 5, 00608-20 (IF- 4.28). 10.1128/mSphere.00608-20.

  21. S. Pal, N. Medatwal, S. Kumar, A. Kar, V. Komalla, P. S. Yavvari, D. K. Mishra, D. Malakar, M. Pillai, A. Srivastava, R. D. Sharma, S. Sengupta, U. Dasgupta* and A. Bajaj (2019) A Localized Chimeric Hydrogel Therapy Targets Tumor Microenvironment through Alteration of Sphingolipid Metabolism.  ACS Central Sci. 5, 1648-1662. (IF- 18.7). 10.1021/acscentsci.9b00551.

  22. S. Kumar, J. Thakur, K. Yadav, M. Mitra, S. Pal, A. Ray, S. Gupta, N. Medatwal, R. Gupta, D. Mishram P. Rani, S. Padhi, P. Sharma, A.  Kapil, A. Srivastava, U. Dasgupta, U.D. Priyakumar, L. Thukral, and A. Bajaj (2019) Cholic Acid-Derived Amphiphile can Combat Gram-Positive Bacteria-mediated Infections via Disintegration of Lipid Clusters. ACS Biomater. Sci. Eng. 5, 9, 4764-4775 (IF- 4.49). 10.1021/acsbiomaterials.9b00706.

  23. N. Medatwal and  U. Dasgupta* (2020) Quantitation of Sphingolipids in Mammalian Cell Lines by Liquid Chromatography–Mass Spectrometry. In: Prasad R., Singh A. (eds) Analysis of Membrane Lipids. Springer Protocols Handbooks: 103-117. Springer, New York, NY. (Book Chapter). 10.1007/978-1-0716-0631-5_7.

  24. U. Dasgupta, T. Bamba,, S. Chiantia, P. Karim, A. N.  Tayoun, I.  Yonamine, S. S. Rawat, R. P. Rao, K. Nagashima, E. Fukusaki, V. Puri, P. J. Dolph, P. Schwille, J. K.  Acharya, and U. Acharya  (2009) Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction. Proc Natl Acad Sci USA. 106, 20063-20068. (IF- 9.412). 10.1073/pnas.0911028106.

  25. J. K. Acharya, U. Dasgupta, S. S. Rawat, C. Yuan, P. D. Sanxaridis, I. Yonamine, P. Karim, K. Nagashima, M. Brodsky, S. Tsunoda, and U. Acharya (2008) Cell Non-Autonomous Function of Ceramidase in Photoreceptor homeostasis.  Neuron 57, 69-79. (IF- 14.403). 10.1016/j.neuron.2007.10.041.

  26. U. Dasgupta, B. L. Dixit, M. Rusch, S. Selleck and I. The (2007) Functional conservation of the human EXT1 tumor suppressor gene and its Drosophila homologue tout velu. Dev. Genes Evol. 8, 555-561. (IF- 2.32). 10.1038/27932.

  27. U. Dasgupta, M. Jain, A. K. Tyagi, and J. P. Khurana (2005) Regulatory elements for light-dependent and organ-specific expression of Arabidopsis thaliana PSBO1 gene encoding 33 kDa polypeptide of the oxygen-evolving complex. Plant Sci. 168, 1633-1642. (IF-3.712). 10.1016/j.plantsci.2005.02.017.

  28. J. P. Khurana, U. Dasgupta, A. Laxmi, D. Kumar, and L. K. Paul (2004) Light control of plant development by phytochromes: a perspective. Proc. Indian National Sci. Acad. B70:375-399.

  29. J. P. Khurana, A. K. Tyagi, P. Khurana, A. Kochhar, P. K. Jain, A. Raychaudhuri, R. Chawla, A. K. Bharti, A. Laxmi and U. Dasgupta, (1999) Molecular genetic analysis of constitutively photomorphogenic mutants of Arabidopsis In: S.K. Sopory, S.C. Maheshwari and R. Oelmuller, (eds), Plant Signal Transduction. Kluwer Academic Publishers, Dordrecht. 10.1007/978-1-4615-1365-0_4.

  30. J. P. Khurana, A. Kochhar, P. K. Jain, U. Dasgupta, A. Raychaudhuri,  and A. K. Tyagi A.K (1998) Photomorphogenic mutants of Arabidopsis display partial plastid differentiation in dark and altered gene expression in young seedlings In: Nath P, Mattoo A, Ranade SR and Weil JH (eds), Molecular Insight in Plant Biology. Oxford and IBN Publishing Co. Pvt. Ltd. New Delhi.

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Patents Applied

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1. U. Dasgupta and R. D. Sharma, A method providing spliced transcripts of Ceramide synthase 2 gene to alter the level of ceramides  to affect tumor regression"   CRN3846, Patent application no. 202011011239.

2. U. Dasgupta and T. Pani, A method using alternative splicing of UDP-Glucose Ceramide Glucosyltransferase (UGCG) as a marker for breast cancer diagnosis and prognosis” Provisional  Patent application no. 202111056492.

 

Research Highlights

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  1. Featured in Vigyan Biopatrika first-author interviews https://biopatrika.com/2023/08/10/hydrogel-chemo-triple-neg-breast-cancer/

  2. Featured by India Bioscience, https://indiabioscience.org/news/2023/near-tumor-injection-of-a- new-nano-drug-exposes-an-eat-me-signal?x-craft-preview=vLVmMeQQB3&token=-HNl47G5RixtJXgjqqRkcTRIcA7GnFCt

  3. Article featured in Hindu https://www.thehindu.com/sci-tech/science/nanomicelles-using-nanoparticles-for-cancer-treatment/article33426073.ece

  4. Featured by India Bioscience, https://indiabioscience.org/news/2019/researchers-combat-tumour-growth-by-packing-three-drugs-into-a-single-biomaterial

  5. Featured in Vigyan Biopatrika first-author interviews https://biopatrika.com/2020/12/28/bp-0025-12-2020-sreekanth-and-animesh/amp/

  6. Featured in Vigyan Biopatrika first-author interviews https://biopatrika.com/2023/02/10/sphingolipids-a-promising-diagnostic-toolset-for-breast-cancer-subtyping-and-prognosis/

  7. Invited article on  “Journey of an Young Investigator“ covered by  IndiaBioscience,  DBT https://indiabioscience.org/columns/journey-of-a-yi/its-never-too-late-to-get-back-to-science

 
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